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While emerging evidence, including preclinical studies, early-phase trials, and limited clinical series, suggests that KD may help overcome treatment resistance by suppressing the PI3K/Akt/mTOR pathway, reducing insulin-like growth factor-1 (IGF-1) signaling, and enhancing cancer cell susceptibility to chemotherapy and targeted therapies, robust data from large, randomized controlled trials (RCTs) remain sparse

Neuroscience 164, 9981008.10.1016/j.neuroscience.2009.09.015 20 BlmlS.WisnowskiJ

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

For CNS-targeted research specifically, topical delivery remains largely impractical because the compound must still reach the brain after crossing the skina double barrier problem

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