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Therefore, to enhance mitochondrial complex I activity, NAD + levels were boosted in fly models of PD with NAM, leading to reduced oxidative stress, including lower ROS levels and DNA damage, as well as improved climbing ability 281

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Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochem HM, et al

Neuron 50:897909 [DOI] [PubMed] [Google Scholar] Wright JW, Clemens JA, Panetta JA, Smalstig EB, Weatherly LA, Kramr EA, Pederson ES, Mungall BH, Harding JW

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