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Statistical analysis All statistical analyses were done using the SPSS 26.0 package (IBM Corp., Armonk, NY, USA)

In an eight-year study on epithalamin, Khavinson et al

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Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990