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10.3390/jcm8122227 96
General dosage guideline: Large animals (Cattle, Horse): 15 ml weekly
The MELK inhibitor OTSSP167 protects intestinal epithelial cells by maintaining a normal composition of gut microbiota and balancing gut microbiota distribution, inhibiting ferroptosis, reducing the expression of pro-inflammatory factors in intestinal tissues, and suppressing the AKT/IKK/P65 and ERK/IKK/P65 signaling cascades in vitro and in vivo, thereby exerting a protective effect on the intestinal tissues of colitis mice [291, 292]
Importantly, Dihexa simultaneously increases expression of anti-inflammatory interleukin-10 (IL-10), suggesting the peptide actively shifts the neuroinflammatory balance toward resolution rather than simply suppressing inflammation
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