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The COVID-19 virus can directly infect the central nervous system and damage the brain tissue and neurons, which may be an important mechanism leading to cognitive impairment

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NHS Guidance on Safe Calorie Reduction and Heart Health The NHS recommends a deficit of around 600 kcal per day for safe weight loss of 0.51 kg per week, advising against very low calorie diets below 800 kcal/day unless medically supervised

They activate different intracellular signaling cascades (cAMP/PKA pathway in fat cells vs incretin signaling in gut and brain)