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2 4 But copper is a double-edged element: free or poorly chaperoned copper participates in redox reactions that generate reactive oxygen species, which is exactly why the body binds it so tightly to carriers

Mitochondrial CYP27B1 is the only enzyme (requires Mg ++ ) that hydroxylates carbon number one in cholecalciferol, activating 25(OH)D3 (Bikle, 2014

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The protocol has to match the individual's requirement, health history, and deficiencies