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It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)

Bioavailability: Regarding B12, the most common form in dietary supplements is cyanocobalamin, a synthetic form of vitamin B12

How your care works Vitamin B12 methylcobalamin B12 is a cofactor for energy metabolism and nervous system function

If you're not dosing fasted in the morning, you're leaving efficacy on the table