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Both lowering the concentration of reductive molecules in the TME and increasing local O 2 levels enhance the potential for ROS generation, providing a foundation for improved SDT efficacy and ICD

known cases of chronic disease under treatment such as tuberculosis, diabetes, hypertension, hypo or hyperthyroidism, pernicious anaemia, Crohns disease and current use of anticonvulsant drugs

Interested in learning more about key signatures

This metabolic shift aligns with ferroptosis research wherein 5-HT and 3-HAA promote tumor cell resistance to ferroptosis

For example, when upregulated expression of drug-resistance genes (e.g., Mdr1/Abcb1) in the intestinal flora is detected, the risk of antibiotic use can be flagged in advance to prevent exacerbation of bacterial resistance