However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine
Inhibition of FSP1: a new strategy for the treatment of tumors (Review)
However, controlled human trials have not been published, making evidence quality substantially lower than for Semax or Selank
doi: 10.1158/0008-5472.CAN-17-1076
Because high-quality human data are limited, there is no universally accepted clearance time, so we emphasize individualized dosing, careful monitoring, and regular re-evaluation rather than assuming it is quickly or completely out of the system after a set number of days