Because the rash developed soon after allopurinol was started, we suspected a severe drug cutaneous eruption like Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), a type IV hypersensitivity reaction, and discontinued allopurinol
TBK1, TANK binding kinase 1
In further research, it was found that the neuroprotection mediated by berberine after ischemia involves the AKT/glycogen synthase kinase-3 (GSK3)/extracellular signal-regulated kinase 1/2 (ERK 1/2) signal pathway, and inhibits Jun amino-terminal kinases (JNK) and caspase-3 activity (Simes Pires et al., 2014)
Other than immune reactions, it had been a general belief that high ASNS protein expression in some of the leukemia blasts contribute to L-asparaginase resistance [87, 88]
PLoS ONE 6 , e29539 (2011)