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It is used clinically and in research for tissue repair, with studies covering tendon and ligament injury, muscle strain, gut lining damage (including ulcers and inflammatory bowel conditions), and post-surgical recovery

Although the large intestine has received a majority of attention in the opioid-induced constipation research field, with studies showing MOR activation in the large intestine during opioid-induced constipation 7 , our study implicates the small intestine is also a critical site for morphine-induced constipation

Trends Immunol (2011) 32:11724

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