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10.1007/s12013-014-9922-7 83 HuC

19 participants with severe obesity (BMI 38.3 5.3 kg/m 2 ) were treated with dietary glycine (100 mg/kg/day) for two weeks

(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

10.1111/j.1749-6632.1993.tb26193.x