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Parallel measurement of redox biomarkers would be essential to demonstrate on-target pharmacodynamic effects
These support the liver, which is central to fat metabolism
Melatonin can reduce the action of PGE-2, allowing the secretion of IL-2, stimulating at the same time Th1 lymphocytes and monocytes to increase the release of other cytokines, such as IL-6, IL-12, IL-27, and TNF-, also regulators of NK cell proliferation [33,48]
In addition, previous studies have shown that cerebrolysin increases the level of the BDNF by inhibiting the activity of glycogen synthase kinase-3 beta (GSK-3) (Wada et al., 2003
