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Furthermore, Aloe-emodin can significantly improve oxidative stress responses, downregulate the expression of HMOX-1 and NRF2, and inhibit ferroptosis levels (139)

Likely, stomach cytoprotection theory (4) holding endothelium protection (5) and peptidergic anti-ulcer cytoprotection therapy (6) may improve approach to the management of abdominal aorta anastomosis and thrombus formation at the site of anastomosis

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We report that the core clock protein BMAL1 regulates astrogliosis in a synergistic manner via a cell-autonomous mechanism, and via a lesser non-cell-autonomous signal from neurons

and may guide intensification of treatment of COVID-19-associated uncontrolled inflammation (Potempa et al., 2020