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The anti-inflammatory role of bilirubin on two-hit sepsis animal model

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" These peptide fragments might play a role in cellular signaling, particularly influencing fibroblasts, which are cells deemed critical for synthesizing new collagen fibers

At the same time, EGT can also selectively inhibit the activity of some Zn- and Cu-requiring metalloenzymes, thus inhibiting the oxidation of these metal ions and preventing them from participating in the formation of ROS in the body ( Owing to its antioxidant properties, EGT plays a powerful cytoprotective role in some important cells and tissues ( 2 O 2 and hemoglobin on arachidonic acid (Spicer et al., 1951

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