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Those with documented deficiency in B12, B1, or B6 Patients with peripheral neuropathy (tingling, numbness, burning extremities) Those with lower back pain and sciatica with a neurological component Diabetic patients especially those on metformin (B12 depletion) Strict vegans the only people with complete B12 dietary absence Elderly adults with impaired B12 absorption Post-gastric or intestinal surgery patients Who Should Use with Caution

Even at trough, just before your next dose, receptor activation remains sufficient to maintain appetite suppression

Homocysteine, methylmalonic acid, and/or holotranscobalamin levels as well as a CBC may also be repeated

Vitamin B12, which most humans get from meat, seafood, and dairy products, is essential for red blood cell production and DNA synthesis

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