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Lower glutathione levels result in the accumulation of certain toxins that were previously kept in check

Finally, designing advanced nanocarriers with improved stability, controlled release, and enhanced tumor penetration will further accelerate the clinical translation of GSH-responsive nanomedicine

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There are at least two processes of aminoglycoside-induced cell death that depend on both the particular aminoglycoside and exposure time (Coffin et al., Future work will address the efficacy of Dihexa as a hair cell protect in mammalian models and against additional aminoglycosides