PPMS, primary progressive multiple sclerosis
Within the TME, nutrient scarcityparticularly of glucose and amino acidscombined with the accumulation of immunosuppressive metabolites such as lactate, adenosine, and kynurenine creates a metabolic niche that impairs the function of antitumor immune cells
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Among these studies, five included clinical trials [1923], and 21 included studies using animal models [9, 11, 2442]
it is only accessible through regulated clinical trials