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Data availability statement All collected data are securely stored in either physical or electronic form, as appropriate

First, it was conducted under fasting conditions because eating is known to decrease the absorption of nicotine 16

Automation Levels Manual, semi-automatic, fully automaticmatch to production scale

Therefore, plain packaging could improve not only tobacco control but also asthma, allergy and COPD prevalence together with the protection of vulnerable groups exposed to second hand smoking

Further studies are needed to assess heterogeneity of effects by race/ethnicity, generalize the findings across tissue types, and understand the functional role of differentially methylated sites in relation to disease development