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Shasha et al., 2016)

Chronic inflammation generally worsens insulin resistance, which is often observed in diabetic patients

Because skeletal muscle consumes the largest amount of serum glucose, mitochondrial dysfunction in this tissue will have the greatest impact on glucose disposal

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Edelblum K.L., Turner J.R

4.3 Pharmacokinetic parameters in Sprague-Dawley rats after intravenous and intramuscular administration A total of 324 SD rats were randomly divided into five groups, including 66 rats in group one, 60 rats each in groups two to four, and 78 rats in group five, with each group comprising half male and half female subjects