glutathione phase 2 metabolism - an overview Glutathione Conjugate - an overview

Gu, X., Zhou, L

To create the glutathione model used in this paper, we took the model from [11] and added the glutathione pathway, homocysteine, cystathionine, cysteine, glutamylcysteine, GSH, and GSSG [Figure 1] from a previous model of glutathione metabolism [14]

The downside to this was that only about 15-20% of it was absorbed through the digestive tract

Besides to its antioxidant nature, GSH is involved in the transfer of amino acids by the gamma-glutamyl cycle as well as in the hormonal metabolism of estrogen, leukotrienes, prostaglandins and as a transduction signal for transcription [3]

Protein carbonylation occurs when carbonyls (C=O) are introduced into proteins through the reactions with free radicals or lipid peroxidation products (malondialdehyde and hydroxynonenal)