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2.4 Administration of NASCOBAL with Other Therapy NASCOBAL should be administered with other therapy(ies) in: Patients with concurrent folate and vitamin B12 deficiency:Administer folic acid in addition to NASCOBAL Patients with concurrent iron and vitamin B12 deficiency:Administer iron in addition to NASCOBAL Patients with correctible causes of vitamin B12 deficiency:Consider measures to treat the underlying condition associated with vitamin B12 deficiency in addition to treatment with NASCOBAL 3

At present, natalizumab, a humanized monoclonal antibody against the cell adhesion molecule 4-integrin, is advantageously used in the treatment of multiple sclerosis and Crohn's disease (24)

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However, translating the promising preclinical results of (-)-Vestitol and Salviolone into clinical success for AD treatment faces several significant hurdles

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