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Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LC

Research Square Preprint2023 Dec 1

FOXO4-DRI inhibited SLE BM-MSC survival and induced apoptosis (normal cell death) more than 2 fold, suggesting that FOXO4-DRI can induce apoptosis of senescent SLE BM-MSCs

GLP-1 Agonists (Semaglutide, Tirzepatide) GLP-1 receptor agonists like semaglutide and tirzepatide produce fat loss primarily through appetite suppression and reduced caloric intake rather than direct fat cell targeting

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