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The vitamin is an important opponent to nitrosative stress [3] Methylcobalamin (functions in the cell plasma as a coenzyme in the methylation cycle) and 5-deoxyadenosylcobalamin (functions in the mitochondria as a coenzyme in the citric acid cycle) are the metabolically active forms of vitamin B12

Since IV infusions often combine B12 with complementary nutrients, the broader formulation can occasionally introduce sensitivities that a standalone B12 shot would not

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However, these preclinical findings do not establish safety for use during human pregnancy, as species differences in placental transfer and fetal metabolism may exist