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Preclinical research in murine senescence models has examined FOXO4-DRI for its capacity to reduce senescent cell burden, with observed improvements in physical function, coat density, and renal histology endpoints in aged subjects

The GHIGF-1 axis The axis runs from the hypothalamus to peripheral tissue in a cascade

Am J Clin Nutr 101, 487495, doi: 10.3945/ajcn.113.075309 (2015)

Because of this precision, they tend to have: High specificity for their targets Shorter halflives (they are broken down relatively quickly) Typically lower immunogenicity (less likely to provoke immune reactions) than larger biologic drugs

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