Consistent with the phosphorylation of Met and the subsequent signalling proteins, the dimeric macrocycles are able to clearly mimic the functional role of hHGF and induce cellular responses in not only model cell lines but also various normal human cells (Figs 4, 5, 6 and Supplementary Figs 13 and 14)
Bose P, Pemmaraju N, Masarova L, Bledsoe SD, Daver NG, Jabbour EJ, Kadia TM, Estrov Z, Kornblau SM, Andreeff M , Cortes JE, Jain N, Borthakur G, Alvarado Y, Huynh-Lu J, Henriquez M, Richie MA, Dobbins M, Zhou L, Pierce SA, Wang X, Pike AM, Garcia-Manero G, Kantarjian HM, Verstovsek S
I see it on the list, but wanted to make sure in-case any ingredients changed/updated
Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications
For International Clinical Trials Day 2026, Angelini Pharma explores the role of First-in-Human trials and the elements that make this phase such a critical milestone in drug development