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A randomized, double-blind, placebo-controlled trial in 88 patients with sepsis and elevated blood concentrations of lactate reported that intravenous thiamin (200 mg twice daily for seven days or until discharge from the hospital) did not decrease lactate concentrations at 24 hours post initiation of treatment the primary endpoint of the trial (104)

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However, there is no definitive evidence of efficacy in humans, and its status remains investigational pending rigorous clinical research

Vitamin A controls neuronal differentiation and neural tube formation [138]