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doi:10.1007/s00330-012-2714-9

Choose models and readouts that align with each components preclinical literature mechanism

Differential effects of oxidants and dexamethasone on -glutamylcysteine synthetase and -glutamyl transpeptidase in alveolar epithelial cells

The disorders are inherited in autosomal recessive, Nrf2 superactivity in an autosomal dominant manner

(2003), in a human study, treated elderly human subjects with epithalamin for two to three years, noting a 1.6-1.8 fold decrease in mortality compared with a control group