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In chronic illnesses, mitochondrial function can become impaired, leading to further fatigue and reduced energy levels

For example, NR3C1-1F DNA methylation was found reduced in patients with ME/CFS and coincides with the hypothalamic pituitary-adrenal (HPA) axis hypofunction hypothesis (75)

Reprod BioMed Online (2013) 26(1):6878

This is very important for those with severe deficiencies

The results showed that the mice that experienced hypoxia for 14 days still had obvious cognitive-behavioral impairment after reoxygenation for 28 days, suggesting that the neurological damage induced by chronic hypoxia was irreversible (Fig