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Fitting nonlinear ordinary differential equation models with random effects and unknown initial conditions using the stochastic approximation expectationmaximization (SAEM) algorithm

Smoking and sleep disturbance: the good and the bad If youre a regular smoker, youre more likely to: take longer to fall asleep once in bed 2 spend a greater amount of time in bed awake, rather than asleep sleep for less time overall spend less time in deep, restorative sleep 3

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Generational bans are nothing short of prohibition a failed experiment with dangerous consequences