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PCOS has transcended the field of obstetrics and gynecology and affects various significant systems throughout the body, seriously threatening womens physical and mental health, affecting their quality of life, and causing lifelong endocrine and metabolic diseases (130, 131) ( Figure 3 )

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Disruptions in the gut microbiome can adversely affect the absorption and metabolism of critical micronutrients, including iodine and selenium, thereby influencing thyroid hormone synthesis and immune regulation

At the end of the 24-h incubation, samples from the donor and the acceptor compartments were collected, then the permeability of SF and EBA markers was tested for 30 min

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