Elderly patients (75+ years) Considerations: Multiple medications increasing interaction risks, reduced kidney/liver function affecting peptide clearance, fragile vessels increasing injection bruising, cognitive changes potentially affecting protocol adherence, fixed incomes limiting expensive interventions
It is essential to distinguish medically indicated B12 replacement therapy from commercially marketed wellness injections, as they serve fundamentally different purposes and are subject to different regulatory oversight
Common reconstitution volumes: 20mg vial + 2mL BAC water = 10mg/mL concentration 40mg vial + 2mL BAC water = 20mg/mL concentration 40mg vial + 3mL BAC water = 13mg/mL concentration Add diluent slowly: Insert the needle into the vial at an angle and allow the water to flow down the inside wall of the vial
Teriparatide is already used clinically in some of these cases, and the preclinical evidence for BPC-157 specifically addressed bone defects that failed to heal in control animals
What about Vinay Prasad of CBER
