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Effect of Omega 5 Fatty Acid as an Adyuvant Treatment to Prednisone in Patients With Severe Alcoholic Hepatitis

Darmaun D, Smith SD, Sweeten S, et al

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Amber 2022 (Univ

Level B Support: The THH study in CFA arthritis mice showed that intervention corrected bile acid profile abnormalities and improved inflammation, but these effects vanished under ABX pseudo-germ-free conditions, placing bile acid metabolic shifts within a microbiota-dependent chain ( Level C Consistency Supplement: Multiple Level C studies indicate broad-spectrum metabolic dysregulation in RA models, with treatment driving regression toward a healthy state across multiple pathways, paralleling microbiota structural improvement and inflammation reduction