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Data availability All RNA-seq data have been deposited in the GEO and are accessible through GEO Series accession numbers GSE272456 (HCT116) and 810 GSE272391 (AKP organoids) or at RNA-seq data of the clinical cohort have previously been deposited at GSE103479 (ref

13 Nonetheless, localized use of skin bleaching agents may be of benefit to pigmentary disorders, thus its important to fully evaluate the safety and efficacy of topical glutathione in this context

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Spearman correlation analysis was used in patient sample experiments