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Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)

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However, inflammatory cytokines can reach the brain, via the blood circulation, vagus nerve and lymphatic system, from the peripheral immune system [89,90]

Worsening intracellular oxidative potential was accompanied by increases in intracellular expression of downstream T2 signature proteins, such as POSTN and CCL26, with nonsignificant increases in inducible NO synthase (iNOS/NOS2

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