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Clozapine demonstrated binding affinity to the following receptors: histamine H 1(K i1.1 nM), adrenergic 1A(K i1.6 nM), serotonin 5-HT 6(K i4 nM), serotonin 5-HT 2A(K i5.4 nM), muscarinic M 1(K i6.2 nM), serotonin 5-HT 7(K i6.3 nM), serotonin 5-HT 2C(K i9.4 nM), dopamine D 4(K i24 nM), adrenergic 2A(K i90 nM), serotonin 5-HT 3(K i95 nM), serotonin 5-HT 1A(K i120 nM), dopamine D 2(K i160 nM), dopamine D 1(K i270 nM), dopamine D 5(K i454 nM), and dopamine D 3(K i555 nM)

Falling young adult smoking rates mainly contributed to this decline

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This approach utilizes genetic variants as instrumental variables, effectively mitigating confounding biases and reverse causation inherent in conventional observational studies