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however, in phase 1 clinical trial, BIIB078 failed to exert meaningful effects on CNS pathologies and had no significant impact on neurofilament levels but paradoxically increased inflammatory marker CCL26, and its development has been discontinued (van den Berg et al., 2024

Spinal cord sections were washed with PBS three times at room temperature and incubated with 3% BSA for 1 h

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10.1038/s41598-025-12255-5 8 ChangY.TianY.ZhouD.YangL.LiuT

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