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the calculated stability l n based on single phase exponential decay for Norleual was 4.6 min and for D-Nle-Tyr-Ile-NH-(CH 2 )5-CONH 2 stability t 1/2 was 79.97 min

The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies