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Known Side Effects Reported side effects are generally mild and infrequent: Injection site reactions: temporary redness, mild swelling, or tenderness Nausea: occasionally reported, usually mild and transient Dizziness: rare, typically with first doses Fatigue: some users report temporary tiredness Headache: infrequent, usually resolves quickly These effects typically diminish with continued use and rarely require treatment discontinuation

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Expensive for sustained use

Preexisting SARS-CoV-2 cross-reactive T cells have been widely identified and are detected in up to three-quarters of individuals using sensitive assays and in vitro expansion [43, 67, 88,89,90,91]

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