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Protection of the C-terminus is achieved via substitution of a glycine for the native proline at residue 171 (P171G) relative to mature (i.e., signal peptide removed) human FGF21, preventing degradation by FAP

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Side effects are rare and typically mild, such as occasional skin sensitivity or temporary redness during the introductory phase, particularly at higher concentrations

However, ROS overproduction can trigger pathological responses damaging cells and tissues

Transfer hydrogenation reactions reduce naturally occurring substrates inside the cancer cells in the presence of a catalyst and a natural hydride source