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Most US residents get enough of vitamin B12 in their regular diet, but certain groups should be extra mindful of their risk for B12 deficiency and know to keep an eye out for signs and symptoms

Vitamin B 12 deficiency, like folate deficiency, may lead to decreased synthesis of methionine and S-adenosylmethionine (SAM), thereby adversely affecting methylation reactions

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To do this, its best to discuss all supplements and medical conditions with your healthcare provider