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Finally, although our flow cytometry panel comprehensively quantified key tearfluid mediators, it was not designed to delineate the intracellular signaling cascades or upstream regulators driving G-OSD which herein appears as a multifaceted clinical condition

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Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30(1-2):1-12. doi:10.1016/j.mam.2008.08.006

In the hours to days following the initial injury, neuronal and glial dysfunction, metabolic changes, neuroinflammation, and the release of signaling and inflammatory molecules from neurons, glial cells, and immune cells occur