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Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gutmetabolismreproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (104)

et al, 2015 (83) showed that Se has a beneficial effect in a cohort of hyperthyroid and Se-deficient patients treated with methimazole and L-T4 under a block-and-replace regimen

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Adults with deficiency saw big improvements in symptoms

10.1093/humrep/des173 124