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They will help to stimulate the NRF2 pathway

You should be able to find a sweet spot where you feel great and dosage between 1-3mg daily

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Istradefylline also improved UPDRS Part III scores during the ON phase at both doses, with a stronger effect at 40 mg/day (SMD = -0.24, 95% CI = -0.37 to -0.11, p = 0.0002) than at 20 mg/day (SMD = -0.15, 95% CI = -0.27 to -0.02, p = 0.02)