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The most studied SH with regards to inflammation, 2,5-dimethoxy-4-iodoamphetamine (DOI), has been shown to profoundly suppresses TNF- mediated inflammation in rodent tissues at picomolar concentrationsequating to a dose in humans at least two orders of magnitude below what is necessary to produce hallucinogenic effects [185, 193, 194]

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Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

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