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A similar model of both de novo Put-GABA synthesis and reuptake of extracellular Put-GABA (and potentially also some non-cell-autonomous GABA) via GAT1 offers considerable advantages

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In amphetamine-induced stereotypy models (a pre-clinical model of schizophrenia-like conditions), DSIP normalised brain metabolism and MAO activity disrupted by long-term amphetamine treatment, establishing a role for adrenergic system normalisation as a mechanism of DSIPs neuroprotective activity

doi: 10.1007/s43032-020-00298-0 97 HeFWangFYangYYuanZSunCZouHet al

The rat caudal vertebrae were frozen in the transverse position with the intervertebral disc as the center and stored at 20 C