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Indeed, riboflavin suppresses the cortical neuronal endogenous release of glutamate via reduction in the activity of presynaptic voltage-gated calcium channels, inhibiting the exocytosis of glutamate vesicles (81)

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This reduced effect of FMD in the P72 over the R72 group was still evident in a refeeding phase, where patients had no nutritional restrictions for 1 week after the third FMD cycle

As scientists note, the gut microbiota regulates lipid metabolism, fat breakdown, satiety, and other factors involved in weight management