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Mechanism Ipamorelin selectively activates the ghrelin receptor on pituitary somatotrophs, producing a brief pulse of growth hormone release without significant activation of ACTH, cortisol, prolactin, FSH, LH, or TSH pathways distinguishing it from earlier GHRPs (GHRP-2, GHRP-6) which show off-target endocrine effects

7.0 = dark red erythema with edema or vesicles, potentially extending beyond the test site