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Transforming growth factor- (TGF-) is the cornerstone in this process

Interestingly, fisetin has been reported to restore tissue homeostasis, reduce age-related pathology, and extended median and maximum lifespan in wild-type mice (51)

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The study by Oehler and colleagues in 2002 (34) examined pathologic changes of the synovial membrane in patients with early-stage OA and identified four histological patterns of OA-associated synoviopathy: (i) synovial lining hyperplasia, (ii) sublining and capsular fibrosis, (iii) macromolecular cartilage and bone debris (detritus-rich), and (iv) inflammatory manifestations and stromal vascularization ( Figure 2 ) (29, 3538)

Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility