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COMPETING INTERESTS DDG has been a consultant and/or received grant support from AbbVie, Amgen, BMS, Eli Lilly, Galapagos, Gilead, Janssen, Novartis, Pfizer, and UCB

People with Down syndrome have a relatively low methylation functional status compared to people without Down syndrome

Walnut-derived peptide PW5 ameliorates cognitive impairments and alters gut microbiota in APP/PS1 transgenic mice

Laboratory studies show GHK-Cu naturally occurs in human blood plasma, saliva, and urine[1]

So it may be good to check your homocysteine and MMA levels at least once, even if you take vitamin B12 supplements, just to avoid any unpleasant surprises